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KMID : 0371420190970010015
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Annals of Surgical Treatment and Research
2019 Volume.97 No. 1 p.15 ~ p.20
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The correlation between serum vascular endothelial growth factor (VEGF) and tumor VEGF receptor 3 in colorectal cancer
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Goulart Andre
Ferreira Carla
Rodrigues Ana
Coimbra Barbara
Sousa Nuno
Leao Pedro
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Abstract
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Purpose: Despite plasma biomarkers offering a number of advantages over tissue-based markers, the relationship between serum vascular endothelial growth factor (VEGF) and VEGF receptor (VEGF-R) tumor expression in colorectal cancer (CRC) is still unclear. This study was designed to establish the relationship between the concentration of serum VEGF and tumor VEGF-R expression in patients with CRC.
Methods: A prospective study of consecutive patients undergoing elective colorectal surgery during 1 year. Preoperative VEGF was determined by enzyme-linked immunosorbent assay and VEGF-R3 by immunochemistry.
Results: The initial sample included 134 patients with CRC diagnosis. Results showed significant association of serum values of VEGF with VEGF-R3 expression (P < 0.001), even in the presence of confounders (sex, age, body mass index, tumor location, and surgical approach). The estimated effect size was high (η2 = 0.35).
Conclusion: Serum VEGF has a significant correlation with tumoral VEGF-R3 expression in CRC.
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KEYWORD
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Colorectal neoplasms, Vascular endothelial growth factors, Enzyme-linked immunosorbent assay, Immunohistochemistry
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